Fig. 2.

Potentiation of bradykinin evoked coughing in conscious guinea pigs following pretreatment with the peptidase inhibitors captopril and thiorphan. Both compounds (0.1 mM) were delivered via aerosol to guinea pigs for 5 min prior to bradykinin challenge. Control animals were similarly pretreated with the vehicle for captopril and thiorphan (saline). Bradykinin challenges were given over 10 min and the total number of coughs evoked was recorded. In the absence of the peptidase inhibitors, the concentration of bradykinin required to evoke coughing was =5 mg/ml. Each bar represents the mean±sem of five experiments.