Table 3.
Progression rates for males and females stratified by baseline estimated glomerular filtration rate (eGFR; ml/min/1.73 m2)
| Males | Females | |||
|---|---|---|---|---|
| Parameter | eGFR ≥60 (n = 117) | eGFR <60a (n = 28) | eGFR ≥60 (n = 42) | eGFR <60a (n = 13) |
| eGFR slope (ml/min/1.73 m2/year)b | ||||
| Mean (SEM) | −3.0 (0.1) | −6.8 (1.5) | −0.9 (0.9) | −2.1 (1.6) |
| Time from baseline eGFR to last eGFR (years) | ||||
| Mean (SD) | 8.5 (6.8) | 2.4 (2.5) | 7.8 (7.2) | 4.3 (2.5) |
| Median | 6.7 | 1.3 | 5.6 | 4.4 |
| Baseline age (years) | ||||
| Mean (SD) | 27.8 (12.0) | 41.9 (10.5) | 38.7 (13.1) | 52.1 (13.6) |
| Median | 27.0 | 42.0 | 38.7 | 50.7 |
SEM, standard error of the mean; SD, standard deviation; eGFR, estimated glomerular filtration rate.
P-values for differences males versus females; eGFR ≥60: P = 0.043; eGFR <60: P = 0.037. eGFR assessments after the start of dialysis or transplant or serum creatinine >6 mg/dl (530 μmol/l) are not used in computation of eGFR slopes. Based on a mixed model with fixed effects for intercept, slopes and covariate adjustment for baseline eGFR values along with random effects for individual patient intercepts and slopes.
aCKD defined as eGFR <60 ml/min/1.73 m2.
bPatients with three or more eGFR assessments were included in the eGFR slope calculations.