Fig. 2.

Effect of KIOM-79 on voltage-gated Na⁺ current (I_Na) in rat ventricular myocytes. (A) A representative trace of membrane currents in rat ventricular myocytes obtained with Cs⁺ pipette solution. A transient I_Na was activated with a test depolarization (-35 mV) from holding potential of -80 mV. The I_Na was decrease by 10 µg/mL KIOM-79 (arrow). (B) Summary of the effects of KIOM-79 on the peak amplitude of I_Na. In each cell, the current amplitudes measured at the peak of current were normalized to the control amplitude and mean±SEM values were plotted (n=6). ^*P value <0.05.