Table 3.
Genotype distributions and minor allele frequencies of TRPC1 polymorphisms: American Caucasians (a) and African Americans (b)
| a American Caucasians in GoKinD | ||||||||
|---|---|---|---|---|---|---|---|---|
| dbSNPrsID |
Group |
Gender |
Genotype |
MAF |
pvalue |
OR(95%CI) |
||
| rs7621642 | GG | GA | AA | |||||
| T1Dwith DN | female | 161 (60.8) | 93 (35.1) | 11(4.1) | A 0.217 | 0.045∗ | 1.336(1.005–1.774) | |
| male |
195 (62.7) |
102 (32.8) |
14 (4.5) |
A 0.209 |
0.661∗ |
|||
| T1D without DN | female | 241 (67.9) | 106 (29.9) | 8 (2.2) | A 0.172 | |||
| male |
147 (61.0) |
82 (34.0) |
12 (5.0) |
A 0.220 |
||||
| rs2033912 | AA | AT | TT | |||||
| T1Dwith DN | female | 161 (60.8) | 93 (35.1) | 11(4.1) | T 0.217 | 0.047∗ | 1.331(1.003–1.768) | |
| male |
196 (62.6) |
103 (32.9) |
14 (4.5) |
T 0.209 |
0.694∗ |
|||
| T1D without DN | female | 242 (67.8) | 107 (30.0) | 8 (2.2) | T 0.173 | |||
| male |
148 (61.1) |
82 (33.9) |
12 (5.0) |
T 0.219 |
||||
| rs3821647 | GG | GA | AA | |||||
| T1D with DN | female | 172 (64.9) | 87 (32.8) | 6 (2.3) | A 0.187 | 0.096 | ||
| male |
200 (63.9) |
106 (33.9) |
7 (2.2) |
A 0.192 |
0.946 |
|||
| T1D without DN | female | 256 (71.7) | 94 (26.3) | 7 (2.0) | A 0.151 | |||
| male | 157 (64.9) | 78 (32.2) | 7 (2.9) | A 0.190 | ||||
| b African Americans from Wake Forest | ||||||||
| rs7621642 | GG | GA | AA | |||||
| T2D with ESRD | female | 16 (9.2) | 74 (42.5) | 84 (48.3) | G 0.305 | 0.847∗∗ | ||
| male |
13 (12.6) |
40 (38.8) |
55 (50.9) |
G 0.306 |
0.382∗∗ |
|||
| HTN with ESRD | female | 18 (14.4) | 42 (33.6) | 65 (52.0) | G 0.312 | 0.204∗∗∗ | ||
| male |
11(7.0) |
63 (40.1) |
83 (52.9) |
G 0.271 |
0.392∗∗∗ |
|||
| ND | female | 9 (6.8) | 51 (38.6) | 72 (54.6) | G 0.261 | |||
| male |
15 (10.0) |
60 (40.3) |
74 (49.7) |
G 0.302 |
||||
| rs2033912 | AA | AT | TT | |||||
| T2D with ESRD | female | 14 (8.1) | 71 (41.0) | 88 (50.9) | A 0.286 | 0.416∗∗ | ||
| male |
12 (11.2) |
36 (33.7) |
59 (55.1) |
A 0.280 |
0.365∗∗ |
|||
| HTNwith ESRD | female | 11(8.8) | 42 (33.6) | 72 (57.6) | A 0.256 | 0.722∗∗∗ | ||
| male |
11(6.9) |
56 (35.2) |
92 (57.9) |
A 0.245 |
0.261∗∗∗ |
|||
| ND | female | 9 (6.8) | 46 (34.9) | 77 (58.3) | A 0.242 | |||
| male |
14 (9.4) |
57 (38.3) |
78 (52.3) |
A 0.285 |
||||
| rs3821647 | AA | AG | GG | |||||
| T2Dwith ESRD | female | 11(6.3) | 50 (28.8) | 113 (64.9) | A 0.207 | 0.142∗∗ | ||
| male |
9 (8.3) |
38 (35.2) |
61 (56.5) |
A 0.259 |
0.070∗∗ |
|||
| HTN with ESRD | female | 10 (7.9) | 45 (35.7) | 71 (56.4) | A 0.258 | 0.612∗∗∗ | ||
| male |
7 (4.4) |
47 (29.8) |
104 (65.8) |
A 0.193 |
0.033∗∗∗ |
0.663(0.454–0.969) |
||
| ND | female | 6 (4.6) | 51 (38.6) | 75 (56.8) | A 0.239 | |||
| male | 7 (4.7) | 65 (43.6) | 77 (51.7) | A 0.265 | ||||
T1D = Type 1 diabetes; DN = diabetic nephropathy; T2D = type 2 diabetes; ESRD = end-stage renal disease; HTN = hypertension; ND = non-diabetic subjects; MAF = minor allele frequency. Comparison analyses of ∗ T1D with DN vs. T1D without DN, ∗∗ T2D with ESRD vs. ND, and ∗∗∗ T2D with DN vs. HTN with ESRD. Figures in parentheses are percentages.