Table 2.

Comparison of clinical and laboratory phenotypes of prediabetic ZDF (fa/fa) rats treated with TGZ for 6 weeks vs. untreated ZDF (fa/fa) controls

Parameter	Age, weeks	ZDF (+/+) rats (n = 5)	ZDF (fa/fa) rats
			Untreated (n = 5)	TGZ-treated (n = 6)
Food intake, g/day	7		36.0  ± 1.4	32.8  ± 1.2
	13		38.2  ± 3.0	40.3  ± 1.3
Plasma glucose, mg/dl	7		114.8  ± 5.6	117.0  ± 6.1
	13	90.8  ± 2.6	246.6  ± 26.1	102.5  ± 6.6*
Plasma insulin, μU/ml	7		151.0  ± 46.1	149.6  ± 36.1
	13	53.5  ± 8.6	>250	141.3  ± 27.2*
Plasma leptin, ng/ml	7		24.8  ± 2.0	23.6  ± 2.6
	13		47.2  ± 2.1	41.7  ± 4.3
Plasma triglyceride, mg/dl	7		208.9  ± 26.3	208.5  ± 29.4
	13	63.4  ± 2.7	502.9  ± 57.3	103.3  ± 12.7*
Plasma FFA, mM	7	0.8  ± 0.1	1.88  ± 0.3	1.6  ± 0.1
	13	1.2  ± 0.2	2.23  ± 0.2	1.6  ± 0.3*
Liver triglyceride content, mg/g of wet weight	13	2.5  ± 0.1	13.5  ± 1.6	5.1  ± 0.5*
Islet triglyceride content, ng per islet	13	30.7  ± 2.8	406.0  ± 16.0	266.2  ± 4.8*
Body weight, g	7		254.6  ± 15.4	250.3  ± 10.3
	13	278.0  ± 6.2	474.6  ± 17.9	520.0  ± 11.6§
Liver weight, g	13	11.7  ± 0.5	22.9  ± 1.7	17.2  ± 1.1§
Epididymal fat weight, g	13	1.7  ± 0.1	10.8  ± 0.8	16.2  ± 1.3*

*, P < 0.005;  

^§, P < 0.05 between untreated ZDF (fa/fa) rats and ZDF rats treated with TGZ.