Table 3.

Comparison of Sprague–Dawley rats after 4% or 60% dietary fat content treatment for 6 weeks

Parameter	Sprague–Dawley rats
	Control (n = 4)	High-fat diet (n = 3)
Phenotype
Food intake, Kcal/day	119.6  ± 3.1	137.2  ± 3.1*
Plasma glucose, mg/dl	77.2  ± 4.3	151.9  ± 3.2*
Plasma insulin, microunits/ml	37.5  ± 10.0	87.5  ± 10.0*
Plasma leptin, ng/ml	1.6  ± 0.3	11.5  ± 1.7*
Plasma triglyceride, mg/dl	78.8  ± 4.4	186.7  ± 12.4*
Liver triglyceride content,  mg/g wet weight	2.3  ± 0.5	6.7  ± 1.0*
Body weight, g	284  ± 10.9	444.3  ± 13.5*
Lipogenic expression in liver
SREBP-1	1.00  ± 0.10	2.88  ± 0.19*
ACC	1.00  ± 0.23	2.21  ± 0.21†
FAS	1.00  ± 0.15	0.64  ± 0.08

*, P < 0.005;  

^†, P < 0.01 as compared to 4% chow-treated Sprague–Dawley rats.