TABLE 2.
SEC genes screened for defects in localization of Pot1p-GFP to peroxisomes
| Gene name | Systematic name | Alternate name(s) | Description of product or functiona |
|---|---|---|---|
| SEC1 | YDR164c | Localized to sites of secretion; dependent on SNARE function | |
| SEC7 | YDR170c | GEF involved in intra-Golgi and ER-to-Golgi transport | |
| SEC11 | YIR022w | 18-kDa subunit of signal peptidase complex | |
| SEC12 | YNR026c | SED2 | GEF involved in initiation of transport vesicle budding from ER |
| SEC13 | YLR208w | ANU3 | COPII complex |
| SEC14 | YMR079w | PIT1 | PtdIns/PtdCho transfer protein involved in export of vesicles from the Golgi apparatus; homolog of mammalian PITPs |
| SEC17 | YBL050w | Required for transport of vesicles between ER and Golgi apparatus | |
| SEC18 | YBR080c | ANU4 | Homolog of mammalian NSF; involved in ER-to-Golgi transport |
| SEC20 | YDR498c | v-SNARE; Golgi-to-ER retrograde transport | |
| SEC21 | YNL287w | COPI complex | |
| SEC26 | YDR238c | COPI complex | |
| SEC27 | YGL137w | COPI complex | |
| SEC32 | YLR078c | BOS1 | v-SNARE; ER-to-Golgi vesicular transport |
| SEC33 | YDL145c | COPI, RET1, SOO1 | COPI complex |
| SEC39 | YLR440c | Unknown function | |
| SEC59 | YMR013c | Lipid synthesis; protein N glycosylation | |
| SEC61 | YLR378c | Translocon | |
| SEC63 | YOR254c | PTL1 | Translocon |
| SEC65 | YML105c | Signal recognition particle complex |
a
GEF, guanine nucleotide exchange factor; PITPs, phosphatidylinositol transfer proteins; NSF, N-ethylmaleimide-sensitive factor.