TABLE 4.

Tandemly arranged paralogs encoding hypothetical proteins with secretion signals^a

Protein ID no.	Location	Group no.	Comment	Microarray signal (log2) or ratio
				CLB	RB	NLB	HBG	HBA	CLB/RB	NLB/RB	HBA/HBG
1449	2:1254101-1255446	1	His rich	12.19	11.63	13.13	12.19	12.64	1.47	2.94	1.36
1450	2:1256515-1257396	1	His rich	11.67	11.40	12.88	13.31	13.53	1.21	2.89	1.17
2035*	3:80684-81631	13		10.95	10.47	11.47	12.54	10.46	1.40	2.10	0.23
2036*	3:82673-83620	13		12.19	11.89	12.04	12.90	11.66	1.23	1.11	0.42
4931*	8:357446-358764	4	3′ TMH	13.52	14.48	14.26	13.21	13.07	0.51	0.86	0.91
4932*	8:359380-360704	4	3′ TMH	13.98	14.29	13.93	14.74	14.54	0.80	0.78	0.87
8377	16:485910-487103	2		11.79	11.65	12.00	11.20	12.43	1.10	1.28	2.34
8378	16:487758-488977	2		12.56	12.34	13.55	13.01	13.74	1.16	2.44	1.67

^aProtein model numbers (v2.1), location, expression levels and ratios. The media CLB, RB, NLB, HBG, and HBA, are defined in Materials and Methods. TMH, transmembrane helices. Protein identification numbers designated with “*” were identified by LC-MS/MS (see Table S3 in the supplemental material). As described in the text, CLUSTAL W analysis of hypothetical proteins distinguished 16 “groups” of related sequences.