TABLE 1.

Genes induced in wild-type M. tuberculosis, relative to the levels for the Δ-σ^H mutant, at 0 min PDS^a

Function	Locus tag	Gene	Fold expression		P
			Pre-diamide stress	0 min PDS
Heat shock	Rv0384c	clpB	1.148 ± 0.043	3.760 ± 0.559	0.043
	Rv3417c	groEL1	1.051 ± 0.047	4.266 ± 0.768	0.049
	Rv3418c	groES	1.051 ± 0.047	2.562 ± 0.282	0.050
	Rv0251c	hsp	0.951 ± 0.048	2.141 ± 0.143	0.018
	Rv0350	dnaK	1.068 ± 0.004	2.902 ± 0.416	0.050
	Rv0469	dnaJ1	1.003 ± 0.026	2.607 ± 0.321	0.040
Transcription	Rv2710	sigB	0.998 ± 0.017	1.998 ± 0.159	0.042
	Rv1221	sigE	0.874 ± 0.0004	2.602 ± 0.392	0.050
	Rv3223c	sigH	0.869 ± 0.029	3.471 ± 0.502	0.045
	Rv0014c	pknB	0.926 ± 0.120	1.902 ± 0.111	0.002
	Rv1674c		1.056 ± 0.125	5.065 ± 0.181	0.003
Transport	Rv2397c	cysA1	0.944 ± 0.006	2.622 ± 0.324	0.043
	Rv2399c	cysT	0.831 ± 0.035	2.146 ± 0.229	0.043
	Rv2398c	cysW	1.110 ± 0.012	2.085 ± 0.139	0.035
	Rv1859	modC	1.208 ± 0.035	2.128 ± 0.239	0.049
	Rv0924c	mntH	0.909 ± 0.003	1.862 ± 0.196	0.046
	Rv1473		0.876 ± 0.003	1.774 ± 0.087	0.016
Detoxification	Rv2641	cadI	0.965 ± 0.016	4.139 ± 0.680	0.048
	Rv3913	trxB2	0.979 ± 0.018	4.550 ± 0.780	0.047
	Rv2899c	fdhD	1.234 ± 0.010	3.036 ± 0.310	0.039
Molybdopterin biosynthesis	Rv2453c	mobA	1.236 ± 0.025	3.301 ± 0.430	0.048
	Rv3206c	moeB1	1.095 ± 0.015	3.209 ± 0.018	0.003
Sulfate metabolism	Rv1336	cysM	0.914 ± 0.058	5.058 ± 0.173	0.006
	Rv1286	cysN	0.774 ± 0.246	3.511 ± 0.827	0.047

^aThe functional categorization of M. tuberculosis genes was based on their known functions as assigned by the TubercuList database (http://genolist.pasteur.fr/TubercuList/). For each gene, the changes in wild-type M. tuberculosis relative to the levels for the Δ-σ^H mutant in the pre-diamide stress samples and the 0-min-PDS samples are shown, along with standard deviations. Statistical significance was assigned using the ANOVA function within the S⁺ ArrayAnalyzer script.