TABLE 4.

Genes repressed in wild-type M. tuberculosis, relative to the levels for the Δ-σ^H mutant, at 30 min PDS^a

Function	Locus tag	Gene	Fold expression		P
			Pre-diamide stress	30 min PDS
Lipid metabolism	Rv0973c	accA2	1.206 ± 0.105	0.265 ± 0.061	0.039
	Rv0904c	accD3	1.059 ± 0.029	0.590 ± 0.058	0.041
	Rv3252c	alkB	1.427 ± 0.029	0.213 ± 0.041	0.013
	Rv2243	fabD	0.784 ± 0.062	0.357 ± 0.056	0.002
	Rv0859	fadA	1.548 ± 0.045	0.428 ± 0.193	0.047
	Rv2590	fadD9	0.985 ± 0.008	0.498 ± 0.111	0.047
	Rv3089	fadD13	0.965 ± 0.022	0.098 ± 0.005	0.004
	Rv0244c	fadE5	0.968 ± 0.036	0.229 ± 0.009	0.014
	Rv2724c	fadE20	1.261 ± 0.024	0.475 ± 0.102	0.036
	Rv0469	umaA	1.214 ± 0.008	0.567 ± 0.095	0.030
Intermediary metabolism	Rv3086	adhD	1.421 ± 0.187	0.049 ± 0.018	0.027
	Rv3841	bfrB	0.762 ± 0.002	0.182 ± 0.132	0.050
	Rv3617	ephA	0.961 ± 0.038	0.431 ± 0.063	0.043
	Rv3854c	ethA	0.844 ± 0.019	0.097 ± 0.016	0.00008
	Rv3251c	rubA	1.003 ± 0.051	0.161 ± 0.132	0.048
	Rv3250c	rubB	1.220 ± 0.059	0.175 ± 0.085	0.031
Cell wall associated	Rv0341	iniB	0.301 ± 0.163	0.294 ± 0.134	0.050
	Rv3084	lipR	1.412 ± 0.009	0.049 ± 0.028	0.006
	Rv1217c		1.120 ± 0.009	0.273 ± 0.054	0.011
	Rv2846c		0.908 ± 0.085	0.293 ± 0.083	0.035

^aThe functional categorization of M. tuberculosis genes was based on their known functions as assigned by the TubercuList database (http://genolist.pasteur.fr/TubercuList/). For each gene, the changes in wild-type M. tuberculosis relative to the levels for the Δ-σ^H mutant in the pre-diamide stress samples and the 30-min-PDS samples are shown, along with standard deviations. Statistical significance was assigned using the ANOVA function within the S⁺ ArrayAnalyzer script.