TABLE 6.

Genes repressed in wild-type M. tuberculosis, relative to the levels for the Δ-σ^H mutant, at 60 min PDS^a

Function	Locus tag	Gene	Fold expression		P
			Pre-diamide stress	60 min PDS
Lipid metabolism	Rv0973c	accA2	1.203 ± 0.105	0.488 ± 0.023	0.040
	Rv2247	accD6	0.840 ± 0.009	0.600 ± 0.027	0.035
	Rv3252c	alkB	1.427 ± 0.029	0.250 ± 0.025	0.010
	Rv1094	desA2	0.655 ± 0.006	0.394 ± 0.062	0.048
	Rv1185c	fadD21	1.061 ± 0.057	0.504 ± 0.051	0.002
	Rv3089	fadD13	0.965 ± 0.002	0.220 ± 0.053	0.009
	Rv0404	fadD30	1.135 ± 0.045	0.555 ± 0.037	0.002
	Rv2950c	fadD29	1.051 ± 0.003	0.396 ± 0.033	0.012
	Rv2930	fadD26	1.066 ± 0.022	0.121 ± 0.043	0.012
	Rv1483	fabG1	1.788 ± 0.025	0.421 ± 0.133	0.017
	Rv2524c	fas	0.870 ± 0.047	0.419 ± 0.055	0.050
	Rv2384	mbtA	1.097 ± 0.080	0.545 ± 0.074	0.002
	Rv2382c	mbtC	0.681 ± 0.043	0.424 ± 0.007	0.042
	Rv2381c	mbtD	0.801 ± 0.040	0.375 ± 0.054	0.050
	Rv2379c	mbtF	0.854 ± 0.003	0.488 ± 0.064	0.037
	Rv2931	ppsA	0.991 ± 0.016	0.256 ± 0.100	0.036
	Rv2932	ppsB	0.808 ± 0.067	0.407 ± 0.059	0.004
	Rv2933	ppsC	1.293 ± 0.033	0.337 ± 0.072	0.024
	Rv2934	ppsD	1.303 ± 0.107	0.527 ± 0.205	0.029
	Rv2935	ppsE	0.852 ± 0.001	0.498 ± 0.076	0.047
	Rv0405	pks6	1.068 ± 0.020	0.390 ± 0.010	0.007
Information pathways	Rv0651	rplJ	1.022 ± 0.037	0.566 ± 0.095	0.028
	Rv2442c	rplU	1.051 ± 0.023	0.589 ± 0.022	0.022
	Rv1015c	rplY	0.875 ± 0.008	0.531 ± 0.008	0.011
	Rv2057c	rpmG1	1.032 ± 0.085	0.609 ± 0.016	0.036
	Rv0718	rpsH	1.117 ± 0.121	0.500 ± 0.006	0.041
	Rv2055c	rpsR2	0.814 ± 0.013	0.552 ± 0.013	0.017
	Rv0710	rpsQ	1.115 ± 0.030	0.609 ± 0.003	0.013
Transport	Rv0917	betP	0.890 ± 0.022	0.541 ± 0.083	0.039
	Rv2937	drrB	0.781 ± 0.019	0.496 ± 0.002	0.017
	Rv2938	drrC	1.059 ± 0.019	0.527 ± 0.028	0.054
	Rv2846c	efpA	0.906 ± 0.085	0.417 ± 0.085	0.0001
	Rv1811	mgtC	0.941 ± 0.031	0.635 ± 0.008	0.016
	Rv2281	pitB	1.112 ± 0.001	0.490 ± 0.057	0.020
	MT0955	pstS1	1.693 ± 0.007	0.596 ± 0.029	0.007
	Rv1217c		1.120 ± 0.009	0.608 ± 0.064	0.032
	Rv0986		0.789 ± 0.034	0.452 ± 0.109	0.050
	Rv0987		0.996 ± 0.052	0.477 ± 0.049	0.044
	Rv1349		0.904 ± 0.014	0.566 ± 0.060	0.050

^aThe functional categorization of M. tuberculosis genes was based on their known functions as assigned by the TubercuList database (http://genolist.pasteur.fr/TubercuList/). For each gene, the changes in wild-type M. tuberculosis relative to the levels for the Δ-σ^H mutant in the pre-diamide stress samples and the 60-min-PDS samples are shown, along with standard deviations. Statistical significance was assigned using the ANOVA function within the S⁺ ArrayAnalyzer script.