TABLE 7.

Genes induced in wild-type M. tuberculosis, relative to the levels for the Δ-σ^H mutant, at 90 min PDS^a

Function	Locus tag	Gene	Fold expression		P
			Pre-diamide stress	90 min PDS
Lipid metabolism	Rv3667	acs	0.921 ± 0.057	1.722 ± 0.154	0.050
	Rv0468	fadB2	1.355 ± 0.033	2.628 ± 0.040	0.007
	Rv1185c	fadD21	1.106 ± 0.057	2.284 ± 0.167	0.042
	Rv0231	fadE4	1.166 ± 0.016	1.755 ± 0.087	0.026
	Rv0242c	fabG4	1.091 ± 0.023	2.196 ± 0.076	0.010
	Rv1493	mutB	1.106 ± 0.016	1.727 ± 0.172	0.055
	Rv1182	papA3	1.265 ± 0.091	2.071 ± 0.148	0.052
	Rv2946c	pks1	0.850 ± 0.038	1.660 ± 0.225	0.051
	Rv2935	ppsE	0.852 ± 0.001	1.791 ± 0.153	0.036
Transport	Rv2920c	amt	1.029 ± 0.053	1.667 ± 0.197	0.049
	Rv2397c	cysA1	0.944 ± 0.006	2.194 ± 0.056	0.011
	Rv3117	cysA3	1.141 ± 0.014	1.702 ± 0.051	0.014
	Rv2398c	cysW	1.110 ± 0.012	1.778 ± 0.043	0.010
	Rv0908	ctpE	1.030 ± 0.033	1.978 ± 0.262	0.051
	Rv1811	mgtC	0.941 ± 0.031	1.564 ± 0.153	0.001
	Rv2281	pitB	1.112 ± 0.001	2.018 ± 0.211	0.046
	Rv1273c		0.872 ± 0.034	3.093 ± 0.576	0.055
	Rv1458c		1.119 ± 0.024	2.166 ± 0.150	0.027
Cell wall associated	Rv3793	embC	0.953 ± 0.004	1.982 ± 0.211	0.046
	Rv0399c	lpqK	0.974 ± 0.113	4.103 ± 0.553	0.047
	Rv1235	lpqY	1.080 ± 0.035	2.113 ± 0.014	0.004
	Rv1921c	lppF	1.244 ± 0.266	3.160 ± 0.567	0.035
	Rv2945c	lppX	0.783 ± 0.029	2.214 ± 0.272	0.045
	Rv0451c	mmpS4	0.893 ± 0.013	2.082 ± 0.165	0.033
	Rv2350c	plcB	0.974 ± 0.010	2.247 ± 0.272	0.045
	Rv3682	ponA2	1.135 ± 0.019	1.771 ± 0.152	0.046
	Rv0284		0.846 ± 0.015	2.213 ± 0.370	0.050
	Rv1184c		1.486 ± 0.037	3.460 ± 0.010	0.003
PE/PPE family	Rv2768c	PPE43	0.878 ± 0.049	1.850 ± 0.082	0.030
	Rv3478	PPE60	1.150 ± 0.024	1.652 ± 0.140	0.050
	Rv1172c	PE12	0.910 ± 0.0003	1.720 ± 0.174	0.047
	Rv1787	PPE25	1.128 ± 0.003	2.219 ± 0.230	0.047
	Rv2519	PE26	1.047 ± 0.052	1.643 ± 0.189	0.050
	Rv1789	PPE26	0.871 ± 0.037	1.680 ± 0.144	0.049
	Rv1430	PE16	1.013 ± 0.046	1.746 ± 0.209	0.049
	Rv3533c	PPE62	1.117 ± 0.033	2.557 ± 0.390	0.050
			0.890 ± 0.022	0.541 ± 0.083	0.039
Protein processing	Rv3596c	clpC1	1.077 ± 0.015	1.651 ± 0.026	0.016
	Rv2460c	clpP2	1.103 ± 0.014	1.838 ± 0.191	0.051
	Rv2461c	clpP1	1.118 ± 0.011	1.624 ± 0.049	0.016
Transcription	Rv3132c	devS	1.037 ± 0.069	2.556 ± 0.432	0.050
	Rv1479	moxR1	0.875 ± 0.0008	1.965 ± 0.013	0.003
	Rv2088	pknJ	0.984 ± 0.159	1.771 ± 0.326	0.047
	Rv1032c	trcS	1.012 ± 0.080	1.949 ± 0.137	0.044

^aThe functional categorization of M. tuberculosis genes was based on their known functions as assigned by the TubercuList database (http://genolist.pasteur.fr/TubercuList/). For each gene, the changes in wild-type M. tuberculosis relative to the levels for the Δ-σ^H mutant in the pre-diamide stress samples and the 90-min-PDS samples are shown, along with standard deviations. Statistical significance was assigned using the ANOVA function within the S⁺ ArrayAnalyzer script.