TABLE 9.
Function | Locus tag | Gene | Fold expression
|
P | |
---|---|---|---|---|---|
Pre-diamide stress | 120 min PDS | ||||
Transport | Rv1183 | mmpL10 | 0.911 ± 0.221 | 1.666 ± 0.074 | 0.044 |
Rv0929 | pstC2 | 1.086 ± 0.034 | 1.756 ± 0.059 | 0.031 | |
Rv2281 | pitB | 1.112 ± 0.001 | 1.883 ± 0.164 | 0.047 | |
Rv2397c | cysA1 | 0.944 ± 0.006 | 1.610 ± 0.148 | 0.050 | |
Intermediary metabolism | Rv1318c | adc | 1.130 ± 0.295 | 1.996 ± 0.384 | 0.023 |
Rv3303c | lpdA | 1.309 ± 0.026 | 1.809 ± 0.032 | 0.034 | |
Rv0557 | pimB | 1.385 ± 0.021 | 3.026 ± 0.348 | 0.044 | |
Rv0886 | fprB | 1.022 ± 0.077 | 1.841 ± 0.113 | 0.051 | |
Rv0373c | coxM | 1.336 ± 0.029 | 3.246 ± 0.336 | 0.042 |
The functional categorization of M. tuberculosis genes was based on their known functions as assigned by the TubercuList database (http://genolist.pasteur.fr/TubercuList/). For each gene, the changes in wild-type M. tuberculosis relative to the levels for the Δ-σH mutant in the pre-diamide stress samples and the 120-min-PDS samples are shown, along with standard deviations. Statistical significance was assigned using the ANOVA function within the S+ ArrayAnalyzer script.