TABLE 1.
A selection of genes regulated in response to a sublethal LL-37 dose
| Category | ORFa | Description | Fold changeb (time [min])c |
|---|---|---|---|
| Resistance | NMB1955 | Cadmium resistance | 3.59 (30) |
| NMB1715 | mtrD | 2.12 (30) | |
| NMB1763 | Codes for putative toxin-activating protein | 2.24 (30), 2.04 (60) | |
| Capsule | NMB0068 | siaC | 2.57 (30) |
| NMB0067 | siaD | 2.20 (30) | |
| NMB0082 | lipA | 1.33 (30) | |
| Other | NMB0360 | Codes for ampG-related protein | 2.02 (30) |
| NMB0663 | nspA | 0.48 (60) | |
| NMB1628 | Codes for putative tspB protein | 2.14 (30), 1.86 (60) | |
| Hypothetical | NMB1404 | Hypothetical | 3.86 (30), 2.63 (60) |
| NMB0660 | Hypothetical | 3.76 (30), 3.17 (60) | |
| NMB1746 | Hypothetical | 3.28 (30), 3.37 (60) | |
| Housekeeping | NMB0140 | 30S (S10) ribosomal | 1.06 (30), 1.03 (60) |
a
Designations represent N. meningitidis Serogroup B genome sequence open reading frames (ORF) (27).
b
Fold change values represent the ratios of mRNA transcript levels in LL-37-treated strain MC58 to those detected in untreated strain MC58.
c
Values indicate whether the induced regulation occurred after 30 or 60 min of exposure to sublethal LL-37 doses.