FIG. 4.

Selenium supplementation in the presence of auranofin yields an effect similar to that observed with stannous salts. Cultures were grown and optical densities recorded as described in the Fig. 1 legend. Cultures were treated with various concentrations of auranofin (0.068, 0.34, 0.68, 3.4, and 6.8 μg/ml, final concentrations). (A and B) Selenium in the form of sodium selenite (A) or l-selenocysteine (B) were added prior to inoculation. Percent growth (growth yield of inhibited cultures versus the yield of the control) is plotted. Data shown are from at least three independent cultures. Error bars indicate standard deviations.