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. 2009 May 20;3:92–99. doi: 10.2174/1874210600903010092

Table 1.

Growth Factors Found in Platelets in PRFM

Factor Target Cell/Tissue Function
PD-EGF
(epidermal growth factor)

  • Blood vessel cells, outer skin cells

  • Fibroblasts, and many other cell types

  • Cell growth, recruitment

  • Differentiation, skin closure

  • Cytokine secretion
PDGF, A+B
(platelet-derived growth factor)

  • Fibroblasts, smooth muscle cells, chondrocytes, osteoblasts, mesenchymal stem cells

  • Potent cell growth, recruitment

  • Blood vessel growth, granulation

  • Growth factor secretion; matrix formation w/BMPs (collagen and bone)
TGF-β1
(transforming growth factor beta1)

  • Blood vessel tissue, outer skin cells

  • Fibroblasts, monocytes

  • TGF gene family includes the BMPs

  • Osteoblasts – highest levels of TGF-βr

  • Blood vessel (+/-), collagen syn.

  • Growth inhibition, apoptosis (cell death)

  • Differentiation, activation
IGF-1,2
(insulin-like growth factor1,2)

  • Bone, blood vessel, skin, other tissues

  • Fibroblasts

  • Cell growth, differentiation, recruitment

  • Collagen synthesis w/PDGF

VEGF/ECGF
(vascular endothelial GF)

  • Blood vessel cells

  • Cell growth, migration, new blood vessel growth

  • Anti-apoptosis (anti-cell death)
bFGF
(basic fibroblast growth factor)

  • Blood vessels, smooth muscle, skin

  • Fibroblasts, other cell types

  • Cell growth

  • Cell migration, blood vessel growth