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. Author manuscript; available in PMC: 2009 Jun 18.
Published in final edited form as: FASEB J. 2007 Nov 12;22(4):1169–1178. doi: 10.1096/fj.07-9131.com

Figure 1.

Figure 1

5LO is up-regulated in old Tg2576 mice and in AD brains. A) Relative mRNA levels of 5LO were measured in separate anatomical regions of the brains of 3- (young) and 24-month-old (old) Tg2576 mice by real-time quantitative RT-PCR amplification (n=3 mice per group). *P < 0.05; **P < 0.001 significant, old vs. young. B) Representative Western blot analysis of the hippocampal and cortical homogenates from control and AD brains probed with a specific antibody against 5LO. C) Densitometric analysis of 5LO immunoreactivity in control and AD brains. Values represent mean ± SE. *P < 0.05, significant vs. control.