Table 3.
Correlation between age, volume/mass (mL/gram), and Mitral E/A ratio with plasma MMP & TIMP levels
| Age (quintile) |
Age (continuous) |
LV volume/mass (mL/gram) |
Mitral E/A (ratio) |
|
|---|---|---|---|---|
| MMP-2 | 0.35 (<0.01) | 0.14 (<0.01) | −0.10 (0.34) | −0.30 (<0.01) |
| MMP-7 | 0.58 (<0.01) | 0.30 (<0.01) | −0.38 (<0.01) | −0.53 (<0.01) |
| MMP-8 | −0.07 (0.55) | 0.001 (0.9) | 0.03 (0.83) | 0.08 (0.51) |
| MMP-9 | −0.34 (<0.01) | 0.04 (0.07) | 0.19 (0.10) | 0.24 (0.04) |
| TIMP-1 | 0.43 (<0.01) | 0.23 (<0.01) | −0.32 (<0.01) | −0.42 (<0.01) |
| TIMP-2 | 0.32 (<0.01) | 0.22 (<0.01) | −0.03 (0.78) | −0.22 (0.06) |
| TIMP-4 | 0.49 (<0.01) | 0.32 (<0.01) | −0.21 (0.07) | −0.44 (<0.01) |
Abbreviations: LV = Left Ventricular, MMP = Matrix Metalloproteinase, TIMP = Tissue Inhibitor of MMP, all MMP/TIMP values are in ng/ml units. Data were analyzed using a Spearman’s correlation coefficient (ρ) except for “age (continuous)” which was analyzed using a Pearson’s correlation coefficient (r), p value for each correlation coefficient is in parenthesis.