Table 5.

Multivariate Analyses Examining the Effects of Age on MMPs and TIMPs

	Age	Gender	Medications	Age/Gender Interaction
MMP-2	0.04	0.56	0.39	0.44
MMP-7	0.0001	0.51	0.38	0.006
MMP-8	0.24	0.30	0.44	0.39
MMP-9	0.02	0.38	0.59	0.67
TIMP-1	0.0009	0.012	0.02	0.05
TIMP-2	0.28	0.77	0.61	0.33
TIMP-4	0.003	0.98	0.43	0.52
Vol/Mass (mL/gm)	0.0001	0.19	0.45	0.03
RWT	0.0007	0.36	0.85	0.16
Mitral E/A	0.0001	0.18	0.57	0.46
E′ (cm/sec)	0.0004	0.14	0.44	0.78

Abbreviations: MMP = Matrix Metalloproteinase, TIMP = Tissue Inhibitor of MMP, all MMP/TIMP values are in ng/ml units, Vol= left ventricular volume, RWT = relative wallthickness, Mitral E/A ratio = peak early diastolic filling (Mitral E) vs peak late diastolic filling (Mitral A) velocity ratio, E′ = peak early diastolic velocity of the lateral mitral annulus,