Table 2.
Micronuclei induced by acephate in cultured human lymphocytes
| Test substance | Treatment | Binucleated cells (BN) scored | Distribution of BN cells according to the No. of MN | MN (%) | Cytokinesis-block proliferation index (CBPI) | ||||
|---|---|---|---|---|---|---|---|---|---|
| Period (h) | Dose (μg mL−1) | ||||||||
| (1) | (2) | (3) | (4) | ||||||
| Control | 48 | 0.00 | 2,000 | – | – | – | – | 0.00 ± 0.00 | 2.02 ± 0.314 |
| MMC | 48 | 0.20 | 2,000 | 38 | 2 | – | – | 2.00 ± 0.31 | 0.71 ± 0.188 |
| Acephate | 48 | 12.5 | 2,000 | 10 | – | – | – | 0.50 ± 0.16* | 1.99 ± 0.312 |
| 25 | 2,000 | 13 | – | – | – | 0.65 ± 0.18* | 1.91 ± 0.306 | ||
| 50 | 2,000 | 15 | 1 | – | 1 | 1.05 ± 0.23** | 1.74 ± 0.292 | ||
| 100 | 2,000 | 20 | 3 | – | – | 1.30 ± 0.25** | 1.87 ± 0.302 | ||
| 200 | 2,000 | 22 | 3 | – | – | 1.40 ± 0.26** | 1.91 ± 0.306 | ||
* Significantly different from the control p < 0.01 (z-test)
** Significantly different from the control p < 0.001 (z-test)