. 2009 Apr 30;59(2):73–80. doi: 10.1007/s10616-009-9195-y

Table 3.

Frequency of SCE, RI and MI induced by acephate in cultured human lymphocytes

Test substance	Treatment		Min–max SCE	SCE/cell ± SE	M₁	M₂	M₃	RI ± SE	MI ± SE (%)
Test substance	Period (h)	Dose (μg mL⁻¹)	Min–max SCE	SCE/cell ± SE	M₁	M₂	M₃	RI ± SE	MI ± SE (%)
Control	24	0.00	1–8	4.36 ± 0.26	33	50	117	2.42 ± 0.05	11.00 ± 0.41
MMC	24	0.2	20–56	38.30 ± 1.30	82	68	50	0.74 ± 0.09	5.00 ± 0.49
Acephate	24	12.5	6–13	4.64 ± 0.27	41	41	118	1.77 ± 0.07	10.35 ± 0.68
		25	4–19	5.60 ± 0.32	40	48	112	2.36 ± 0.05	9.75 ± 0.66
		50	5–17	10.38 ± 0.56†	32	42	126	2.47 ± 0.04	8.50 ± 0.62**
		100	6–18	11.60 ± 0.50†	34	43	123	2.44 ± 0.04	7.65 ± 0.59***
		200	8–19	12.00 ± 0.39†	21	33	146	2.62 ± 0.05	6.55 ± 0.55***
Control	48	0.00	2–7	3.64 ± 0.24	18	64	128	2.48 ± 0.05	11.93 ± 0.72
MMC	48	0.2	25–83	54.32 ± 2.36	104	50	46	1.71 ± 0.06	4.00 ± 0.44
Acephate	48	12.5	2–19	4.90 ± 0.29	45	52	103	2.30 ± 0.05	10.35 ± 0.68
		25	2–13	7.42 ± 0.37†	31	85	84	2.26 ± 0.05	9.50 ± 0.65*
		50	7–14	9.74 ± 0.34†	35	77	89	2.80 ± 0.06	8.00 ± 0.61***
		100	6–19	11.20 ± 0.60†	25	47	128	2.51 ± 0.03	7.15 ± 0.58***
		200	8–22	12.58 ± 0.44†	32	49	119	2.68 ± 0.04	6.15 ± 0.54***

50 metaphases were scored for each concentration in SCE

200 metaphases were scored for each treatment in RI

2,000 metaphases were scored for each treatment in MI

† Significantly different from the control p < 0.05 (t-test)

* Significantly different from the control p < 0.05 (z-test)

** Significantly different from the control p < 0.01 (z-test)

*** Significantly different from the control p < 0.001 (z-test)