Table 2.
Plasma parameters and renal function in response to the treatment
| Vehicle | CAP | CAPZ + CAP | CAPZ | |
|---|---|---|---|---|
| Hct, % | 44.8±0.9 | 43.9±0.7 | 45.0±0.7 | 45.0±0.8 |
| TP, mg·ml−1 | 58.1±5.5 | 59.9±4.7 | 53.2±5.8 | 63.3±0.9 |
| [Na+]P, mmol·L−1 | 134.7±2.1 | 137.6±4.4 | 134.9±1.7 | 134.8±1.8 |
| [Cr]P, mg/·dL−1 | 0.68±0.08 | 0.59±0.03 | 0.66±0.09 | 0.57±0.04 |
| [Li+]P, mmol·L−1 | 0.24±0.04 | 0.26±0.01 | 0.24±0.02 | 0.25±0.02 |
| FELi, % | 40±11 | 34±8 | 32±6 | 24±1 |
| FENa, % | 1.6±0.3 | 2.1±0.4 | 1.9±0.4 | 1.2±0.1 |
| APR, ml·min−1 | 0.5±0.1 | 1.0±0.3 | 0.6±0.1 | 0.7±0.1 |
| FPR, % | 60±11 | 66±8 | 68±6 | 76±1 |
| FDRNa, % | 95±1 | 94±1 | 94±1 | 95±1 |
| FDRH2O, % | 94±1.1 | 94±0.3 | 93±0.4 | 93±0.5 |
Values are expressed as mean ± SE, n= 5–6 rats. ++ p ≤ 0.01 vs Vehicle, CAPZ + CAP and CAPZ groups. Hct, hematocrit; TP, total protein; [Na+]P, plasma sodium concentration; [Cr]P, plasma creatinine concentration; [Li+]P, plasma lithium concentration; GFR, glomerular filtration rate; FELi, fractional excretion of lithium; FENa, fractional excretion of sodium; APR, absolute proximal reabsorption; FPR, fractional proximal reabsorption; FDRNa, fractional distal sodium reabsorption; FDRH2O, fractional distal water reabsorption.