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. 2009 Jun 25;4(6):e6050. doi: 10.1371/journal.pone.0006050

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Souquière et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Pharmacokinetics of tacrolimus in blood over 5 weeks in three STLV-1-infected mandrills. The grey zone indicates the effective therapeutic dose in humans. Immunological and virological data were analysed at different phases of the experiment: pretreatment corresponds to weeks –2, –1, and 0 (pre); treatment corresponds to weeks 1, 2, and 3 (treat); post-treatment corresponds to weeks 4, 5, 6, 7, and 8 (post). (B) Kinetics of STLV proviral load during immunusuppressive therapy. Each value represents the mean±SD of measurements in triplicate for the three phases of the experiment. (C) Kinetics of STLV proviral load in the three control animals.