Overview of B. animalis subsp. lactis CRISPR locus. The Bala1 CRISPR locus, as it appears in the genome, is shown at the top, with the repeat-spacer region on the left (repeats are represented as black diamonds, and spacers are represented as gray boxes) and cas genes on the right. The repeat-spacer region is shown below for Bl-04 and DSMZ 10140, with repeats shown as black diamonds, spacers shown as numbered gray boxes, the leader shown as a white box, and the terminal repeat shown as a black diamond annotated with a “T.” The bottom panel shows a CRISPR spacer overview where repeats are not included and only spacers are represented, using two-color combinations.