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Characterization of PEGylated LMB-2s
| Connector | Molar ratio of free SH/LMB-2 | Molar ratio of PEG/LMB-2 | IC50, pg/ml | LD50, mg/kg | |
|---|---|---|---|---|---|
| LMB-2 | ASGGPE | 0.1 | 0.0 | 60 | 0.51 |
| Mutant LMB-2 | ASG C GPE | 1.1 | 0.0 | 60 | 0.54 |
| PEG5k-mLMB-2 | 0.0 | 1.1 | 60 | 2.92 | |
| PEG20k-mLMB-2 | 0.0 | 1.0 | 70 | 3.09 |
