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Acute in vivo toxicity of a single i.v. injection of PEGylated LMB-2s in mice
| Groups | Injected dose, mg protein/kg
|
||||||
|---|---|---|---|---|---|---|---|
| 0.23 | 0.45 | 0.68 | 0.90 | 1.8 | 3.6 | 4.8 | |
| LMB-2 | 1/7* | 3/7 | 5/7 | 7/7 | |||
| Mutant LMB-2 | 0/7 | 3/7 | 5/7 | 7/7 | |||
| PEG5k-mLMB-2 | 0/5 | 0/7 | 2/7 | 5/7 | 4/4 | ||
| PEG20k-mLMB-2 | 0/5 | 0/7 | 1/7 | 5/7 | 4/4 | ||
Values reported are number of mice dying divided by number of mice treated.
