TABLE 3.
Summary of the viral loads of controls and vaccinees from day 0 through day 140 postinfectiona
| Day | log10(vRNA copy eq/ml plasma + 1)
|
P value
|
||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Controls
|
Vaccinees
|
Two-sample t test | Permutation teste | |||||||
| n | Mean (log) | Mean | SD | n | Mean (log) | Mean | SD | |||
| 0 | 8 | 1.5 | 31 | 0.0 | 8 | 1.5 | 31 | 0.0 | 1.0000 | 1.0000 |
| 7 | 8 | 3.5 | 2,999 | 1.3 | 7 | 3.0 | 1,001 | 1.3 | 0.5002 | 0.5896 |
| 9 | 8 | 4.5 | 34,358 | 1.3 | 8 | 3.5 | 2,955 | 1.7 | 0.1755 | 0.1699 |
| 11 | 7 | 5.9 | 852,170 | 1.1 | 8 | 4.0 | 10,188 | 2.0 | 0.0410d | 0.0440d |
| 14 | 8 | 6.3 | 1,826,271 | 1.0 | 8 | 4.1 | 13,916 | 2.1 | 0.0272d | 0.0315d |
| 21 | 8 | 5.8 | 567,532 | 1.2 | 8 | 2.9 | 804 | 1.7 | 0.0020d | 0.0037d |
| 28 | 6 | 5.3 | 215,246 | 1.6 | 8 | 2.5 | 322 | 1.5 | 0.0072d | 0.0057d |
| 42 | 7 | 5.0 | 98,083 | 1.6 | 8 | 2.3 | 213 | 1.4 | 0.0048d | 0.0028d |
| 56 | 6 | 5.1 | 119,343 | 1.3 | 7 | 2.3 | 215 | 1.4 | 0.0040d | 0.0076d |
| 84 | 6 | 4.5 | 30,750 | 1.0 | 6 | 2.7 | 530 | 2.0 | 0.0940 | 0.0801 |
| 98 | 1 | 5.6 | 365,001 | 3 | 1.8 | 58 | 0.5 | |||
| 112 | 5 | 4.5 | 33,587 | 1.5 | 5 | 1.8 | 64 | 0.4 | 0.0124d | 0.0079d |
| 140 | 4 | 4.4 | 23,775 | 1.8 | 5 | 2.1 | 126 | 0.9 | 0.0796 | 0.0397d |
| Peakb | 8 | 6.4 | 2,463,240 | 0.9 | 8 | 4.5 | 32,325 | 1.8 | 0.0263d | 0.0247d |
| Avgc | 7 | 4.9 | 77,104 | 1.6 | 8 | 2.3 | 201 | 1.4 | 0.0059d | 0.0090d |
a
Non-missing viral concentrations lower than 30 are set to 30 prior to log transformation.
b
The peak viral load was determined by using the highest viral load for each animal. While the peak of viremia usually occurs at 14 days postinfection, some animals have an early or delayed peak; therefore, this number is slightly higher than the day 14 mean viral load for each group.
c
From day 42 through 140.
d
P < 0.05.
e
The permutation test is not applied when group samples are smaller than four.