TABLE 2.

Parameter estimates obtained by fitting models to the data^a

Modelb	IFN-α concn (U/ml)	R(0) (106 copies/μg RNA)	t0 (h)	ɛin	μ (per day)	g (per day)
Eq. 2	100	2.06 (1.81-2.35)	9.5 (5.1-13.8)	0.972 (0.966-0.988)	0.98 (0.88-1.07)	NAc
Eq. 4	100	2.06 (1.81-2.35)	9.5 (5.1-13.8)	0.972 (0.966-0.978)	0.027 (0.02-0.04)	NA
Eq. 6	100	2.06 (1.81-2.35)	9.5 (3.6-15.4)	0.972 (0.966-0.978)	0.98 (0.85-1.11)	3 × 10−8 (0-0.001)d
Eq. 6	250	2.29 (1.74-3.03)	7.8 (3.1-12.4)	0.927 (0.883-0.970)	2.32 (1.57-3.07)	0.33 (0.217-0.448)

^aBest fits to the frequent sg1b data with 100 and 250 U/ml IFN-α are shown in Fig. 3C. Values in parentheses are 95% CIs. R(0), baseline sg1b RNA concentration; t₀, delay until sg1b RNA starts to decline; ɛ_in, IFN-α effectiveness in blocking sg1b RNA production; μ, sg1b RNA degradation; g, slowing of sg1b RNA production.

^bEq, equation.

^cNA, not applicable. This parameter does not exist in equations 2 and 4.

^dThe lower 95% CI (g = 0) is consistent with a flat second phase.