Table 3.

Relative and absolute fluxes through pathways in glucose production

	Lean Cats	Obese Cats
Endogenous glucose production, mg·kg−1·min−1	2.08±0.46a	1.58±0.46a
2H NMR: fractional sources of plasma glucose, %
Total gluconeogenesis	62±16	65±13
Flux from glycerol to glucose	20±10	21±10
Flux from PEP to glucose	42±15	44±10
Glycogenolysis	38±16	35±13
13C NMR: fluxes relative to citrate synthase
Flux through PEPCK (PC/PEPCK)/CS	4.69±1.47	4.53±1.60
Flux through pyruvate kinase/CS	3.68±1.22	3.61±1.26
Flux from PEP to glucose/CS	1.00±0.42	0.92±0.48
Derived fluxes, mg·kg−1·min−1
Flux from glycogen to glucose	0.77±0.30b	0.57±0.30b
Flux from glycerol to glucose	0.81±0.39d*	0.35±0.24d*
Flux from PEP to glucose	1.8±0.87c	1.29±0.35c
Flux through PEPCK (PC/PEPCK)	7.71±3.2	7.77±3.91
Flux through pyruvate kinase	6.07±2.66	6.41±3.66
Flux through OAA to citrate	1.76±0.83	1.89±1.01

Values are means (± SD) for the combined values of the 12 lean and 12 obese cats.

^*P < 0.001; values with the same superscript differ significantly

^a(P < 0.001,

^bP < 0.02,

^cP < 0.03). *Diet differences was found between lean and obese cats

^d(P < 0.002).