Fig. 2.

Outline of the protocol for part 2. Four skin sites on the ventral aspect of the forearm were randomly chosen. Two were pretreated with local anesthesia (LA) for 2 h; one of these sites was instrumented with a microdialysis probe. A skin site not treated with LA was also instrument with a microdialysis probe This yielded an untreated control, LA treated only, microdialysis fiber only, and both LA and microdialysis fiber. Thereafter, the protocol was the same as for part 1. Skin at both LA-treated sites was tested for sensory loss at the beginning and end of the study.