Enhancement of LTD induced by expression of Aβ42 peptide in muscle cells. A) No effects on LTD by neuronal expression of Aβ42 peptide in elav/y; Aβ/+ larvae. Stimulation paradigm for induction of LTD is depicted. EJCs were recorded in 0.4 mM Ca2+ saline. Horizontal bar = 2 min. B) LTD is enhanced in G7/+; Aβ/+ larvae with muscle expression of Aβ42 peptide. Same induction paradigm as in A. Top panels: representative EJC traces for each genotype. Bottom panels: averaged EJC amplitude normalized to basal level before titanic stimulation. n = 4, 4, 5, 5 for elav/y; +/+, elav/y; Aβ/+, G7/+; +/+ and G7/+; Aβ/+. Scale bars = 10 nA (vertical); 7.5 ms (horizontal).