Figure 6.

ATX alters ischemia and H₂O₂-induced glutamate release in the cortex. A) ATX suppresses ischemia-induced glutamate release in cerebral cortex. Glutamate levels were measured from the dialysates from 60 min before to 60 min after the onset of MCAo. B) ATX suppresses H₂O₂-induced glutamate release in cerebral cortex. Glutamate levels were measured from the dialysates for 60 min before and after H₂O₂ infusion. Pretreatment with ATX significantly reduced H₂O₂-mediated glutamate release. *P < 0.05; 2-way ANOVA.