Figure 1.

Hepatic steatosis in ob/ob mice is alleviated by ω-3-PUFAs. A) Representative photomicrographs of liver sections stained with Oil Red O (top) and hepatic TG levels (bottom) in liver samples from wild-type (n=3) and ob/ob mice (n=14) at different weeks of age. B) Representative photomicrographs and histomorphometrical analysis of liver sections stained with Oil Red O from ob/ob mice receiving either control (CT; n=8) or ω-3-PUFA-enriched (ω-3; n=16) diets for 5 wk. C) Expression of key genes involved in hepatic lipid metabolism (i.e., FASN, PPARα, SREBP-1c, and SCD-1) was determined by real-time RT-PCR in liver samples from ob/ob mice after receiving control or experimental diets. Results are expressed as means ± se; P values vs. wild-type (WT) group (A) or CT group (B, C).