Table 1.

Trabecular bone histomorphometry of the femoral neck and vertebra following three years of alendronate treatment.

Femoral Neck
	Pre-treatment Control	Alendronate 0.2 mg/kg/day	Alendronate 1 mg/kg/day	p Value
MAR [μm/day]	1.24 ± 0.08	0.81 ± 0.06*	0.81 ± 0.07*	<0.001
MS/BS %	17.88 ± 1.52	4.62 ± 0.65*	4.12 ± 1.22*	<0.001
Vertebra
	Pre-treatment Control	Alendronate 0.2 mg/kg/day	Alendronate 1 mg/kg/day	p Value
MAR [μm/day]	1.56 ± 0.09	1.13 ± 0.06*	1.11 ± 0.07*	<0.001
MS/BS %	21.34 ± 1.83	4.15 ± 0.51*	3.30 ± 0.92*	< 0.001

MAR, mineral apposition rate; MS/BS, mineralizing surface per unit bone surface.

^*indicates p < 0.05 vs. Pre-treatment Control.

Data are presented as ± SE mean.