Table 4. Association of GST Risk Genotypes and SPM Risk.
| GST risk genotypes1 | Total | SPM-Free | SPM | P value | HR* (95% CI) | |||
|---|---|---|---|---|---|---|---|---|
| No. | % | No. | % | No. | % | |||
| No. of risk genotypes | 0.096 | |||||||
| 0-1 | 266 | 22.1 | 249 | 22.7 | 17 | 15.7 | 1.0 | |
| 2 | 536 | 44.5 | 491 | 44.8 | 45 | 41.7 | 1.3 (0.7-2.2) | |
| 3 | 250 | 29.0 | 312 | 28.4 | 38 | 35.2 | 1.9 (1.1-3.4) | |
| 4 | 53 | 4.40 | 45 | 4.10 | 8 | 7.4 | 2.6 (1.1-6.1) | |
| Trend | 0.004 | |||||||
| Dichotomized groups | 0.035 | |||||||
| 0-2 risk genotypes | 802 | 66.6 | 740 | 67.5 | 62 | 57.4 | 1.0 | |
| 3-4 risk genotypes | 403 | 33.4 | 357 | 32.5 | 46 | 42.6 | 1.7 (1.2-2.5) | |
1
Risk genotypes:GSTM1 null, GSTT1 null, GSTP1 Ile/Val + Val/Val, and GSTP1 Ala/Ala
*
Adjusted for age, sex, ethnicity, smoking, and alcohol