Table 5.

Penetration studies of moxifloxacin and comparators into aqueous and vitreous humor

Route of Administration	Dosing	Dosage	Moxifloxacin		Gatifloxacin		Ciprofloxacin		Reference
			Aqueous (μg/mL)	Vitreous (μg/mL)	Aqueous (μg/mL)	Vitreous (μg/mL)	Aqueous (μg/mL)	Vitreous (μg/mL)
Topical	1 drop/2 hours × 3 days	43 drops	2.28 ± 1.23	0.11 ± 0.05	ND	ND	ND	ND	Hariprasad et al 2005
	1 drop/6 hours × 3 days	22	0.88 ± 0.88	0.06 ± 0.06	ND	ND	ND	ND	Hariprasad et al 2005
	1 drop/10 min prior to surgery	4 drops	1.80 ± 1.25		0.48 ± 0.34				Kim et al 2005
	4×/day × 3 days plus 3 drops 1 hour prior to surgery	15 drops	1.31 ± 0.46		0.63 ± 0.30		0.15 ± 0.11		Solomon et al 2005
	4 times/day 1 day prior and 1 drop prior to surgery	5 drops	1.86 ± 0.23		0.94 ± 0.15				McCulley et al 2006
	4 drops pre surgery	4 drops	1.55 ± 0.86		0.74 ± 0.66				Katz et al 2005
	4 times a day/1 day before and 4 drops, pre surgery	4 drops	1.61 ± 0.71		0.91 ± 0.54
	4 × 2 days pre op	8 drops	0.38 ± 0.32		0.19 ± 0.23				Ong-Tone et al 2007
	4 × 2 days pre op plus 3 drops 2 hours prior to surgery	11 drops	2.16 ± 1.12		0.82 ± 0.31
	4 × 3 days before surgery	12 drops		0.011 ± 0.008		0.008 ± 0.006			Costello et al 2006
Oral	2 tablets (400 mg) at 14 and 3 hours before surgery	800 mg		1.55 ± 0.33					Fuller et al 2006
	2 tablets, evening prior to surgery and 3 hours before surgery	800 mg	1.34 ± 0.66	1.58 ± 0.80					Hariprasad et al 2006
	Single tablet 1–2 hours before surgery	400 mg	0.21 ± 0.21	0.09 ± 0.09					Vedantham et al 2005
	Single tablet, 10 hours before surgery	400 mg	2.33 ± 0.85						Garcia- Saenz et al 2001
	Single dose Prior to surgery	400 mg	1.17 ± 0.40 (10 hours)						Walter et al 2007
	2 tablets, 12 hours apart	400 mg	1.23 ± 0.55 (12 hours)						Kampougeris et al 2007