FIG. 8.

Schematic illustration of the hypoxia-induced signaling pathway leading to Na,K-ATPase downregulation. Hypoxia increases mitochondrial ROS production and leads to AMPK α1 phosphorylation. Activated AMPK directly phosphorylates PKCζ at T410, and PKCζ in turn phosphorylates the Na,K-ATPase α1 subunit at Ser18, triggering its endocytosis.