Table 2.
Association between PPARγ Pro12Ala and risk of acute coronary syndrome among men and women in the Diet, Cancer and Health Cohort
| PPARγ Pro12Ala | Ncase/Nnon-cases | HRa (95% CI) |
p | HRb (95% CI) |
p | HRc (95% CI) |
p |
| Men | |||||||
| Pro/Pro | 589/664 | 1.0 | 1.0 | ||||
| Pro/Ala | 176/204 | 0.92 (0.73–1.17) |
0.51 | 0.92 (0.72–1.18) |
0.50 | Not relevant | |
| Ala/Ala | 21/12 | 1.99 (0.98–4.05) |
0.06 | 2.12 (1.00–4.48) |
0.05 | Not relevant | |
| Pro/Ala & Ala/Ala | 197/216 | 0.98 (0.78–1.23) |
0.86 | 0.98 (0.77–1.24) |
0.86 | Not relevant | |
| Women | |||||||
| Pro/Pro | 181/581 | 1.0 | 1.0 | 1.0 | |||
| Pro/Ala | 62/193 | 0.96 (0.67–1.36) |
0.80 | 0.93 (0.65–1.35) |
0.75 | 0.96 (0.67–1.40) |
0.85 |
| Ala/Ala | 2/15 | 0.38 (0.08–1.72) |
0.21 | 0.37 (0.08–1.72) |
0.21 | 0.40 (0.08–1.85) |
0.24 |
| Pro/Ala & Ala/Ala | 64/208 | 0.91 (0.65–1.29) |
0.60 | 0.89 (0.62–1.27) |
0.53 | 0.92 (0.64–1.33) |
0.60 |
a) Crude (only adjusted for age)
b) Adjusted for alcohol, smoking and NSAID
c) Adjusted for alcohol, smoking, NSAID, hormone replacement therapy and menopause status