Table 3.
HR for acute coronary syndrome subdivided by alcohol intake and PPARγ Pro12Ala genotype.
| Ncases/Nnon-cases | HR (95% CI) | |||||
| Alcohol intake g/day | Alcohol intake g/day | |||||
| PPARγ Pro12Ala | < 4.0 | 4.0 < × < 12.0 | > 12.0 | < 4.0 | 4.0 < × < 12.0 | > 12.0 |
| Men | ||||||
| Pro/Pro | 98/81 | 127/128 | 364/455 | 1a | 0.86 (0.59–1.28) | 0.70 (0.50–0.98) |
| Pro/Ala | 30/19 | 41/37 | 105/148 | 1.41 (0.73–2.70) | 0.90 (0.64–1.55) | 0.58 (0.39–0.86) |
| Ala/Ala | 4/0 | 4/1 | 13/11 | 40.7 (27.5–60.2) | 2.30 (0.29–18.5) | 1.09 (0.46–2.57) |
| P for interaction | p < 0.0001 | |||||
| Pro/Pro | 98/81 | 127/128 | 364/455 | 1b | 0.91 (0.60–1.37) | 0.69 (0.49–0.99) |
| Pro/Ala | 30/19 | 41/37 | 105/148 | 1.30 (0.67–2.55) | 0.78 (0.44–1.39) | 0.60 (0.39–0.90) |
| Ala/Ala | 4/0 | 4/1 | 13/11 | 25.3 (16.5–38.7) | 3.18 (0.41–24.8) | 1.11 (0.45–2.76) |
| P for interaction | p < 0.0001 | |||||
| Women | ||||||
| Pro/Pro | 76/157 | 50/205 | 55/219 | 1a | 0.52 (0.34–0.80) | 0.52 (0.34–0.79) |
| Pro/Ala | 25/60 | 21/63 | 16/70 | 0.72 (0.41–1.27) | 0.70 (0.39–1.27) | 0.45 (0.23–0.88) |
| Ala/Ala | 1/7 | 0/4 | 1/4 | 0.25 (0.29–2.15) | No estimate | 0.70 (0.08–6.50) |
| P for interaction | 0.34 | |||||
| Pro/Pro | 76/157 | 50/205 | 55/219 | 1b | 0.53 (0.34–0.83) | 0.51 (0.33–0.80) |
| Pro/Ala | 25/60 | 21/63 | 16/70 | 0.73 (0.40–1.31) | 0.71 (0.38–1.31) | 0.44 (0.22–0.88) |
| Ala/Ala | 1/7 | 0/4 | 1/4 | 0.27 (0.03–2.15) | No estimate | 0.52 (0.05–5.30) |
| P for interaction | 0.46 | |||||
| Pro/Pro | 76/157 | 50/205 | 55/219 | 1c | 0.53 (0.34–0.84) | 0.52 (0.33–0.82) |
| Pro/Ala | 25/60 | 21/63 | 16/70 | 0.75 (0.41–1.35) | 0.72 (0.38–1.35) | 0.48 (0.24–0.86) |
| Ala/Ala | 1/7 | 0/4 | 1/4 | 0.29 (0.03–2.59) | No estimate | 0.55 (0.05–5.71) |
| P for interaction | 0.51 | |||||
a) Crude analysis (age adjusted), b) Adjusted for smoking and alcohol intake, c) Adjusted for smoking, alcohol, menopause status and HRT use