Table 1.
PP | DA | VU | |
GTV | |||
distance to field borders | 1 – 3.5 cm | NA | < 1 cm or > 3.5 cm |
prescribed dose | 45 Gy | Neither PP nor VU | < 40.5 Gy or > 49.5 Gy |
ENI | |||
distance to field borders | 1 – 3.5 cm | Neither PP nor VU | contralateral hilum included |
prescribed dose | 27 – 36 Gy | NA | < 27 Gy or > 36 Gy |
Overall treatment time | 21 – 42 days | NA | > 42 days |
Interfraction interval | ≥ 5.5 hrs | 4 – 5.5 hrs or <4 hrs (once) | < 4 hrs more than once |
Organs at risk | |||
Spinal cord | ≤ 36 Gy | Neither PP nor VU | > 39 Gy |
Lung | ≤ 1/2 ipsilateral hemithorax (≤ 2/3, upper lobe tumor) or V20 ≤ 35% |
Neither PP nor VU | > 1/2 ipsilateral hemithorax (> 2/3, upper lobe tumor) or V20 > 40% |
Heterogeneity correction | No | Yes (≤ 10% total dose difference) | Yes (> 10% total dose difference) |
Abbreviations: PP, per protocol; DA, deviation acceptable; VU, violation unacceptable; GTV, gross tumor volume; ENI, elective nodal irradiaton; NA, not applicable; hrs, hours; V20, percentage of the total lung minus PTV receiving ≥ 20 Gy.