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. 2009 May 28;5:26. doi: 10.1186/1744-8069-5-26

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Copyright © 2009 Yang et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Effect of GRO/KC treatment on voltage-dependence of K current activation in IB4-negative cells. Data from Figure 2 were converted to conductance values using the calculated value of the K Nernst potential. Data were fitted with the Boltzmann equation. Top: the transient component showed a small but significant leftward shift of V_1/2, from 14.3 mV in control cells to 8.8 mV in GRO/KC treated cells (p < 0.0005). The Hill slope values were 10.3 and 11.7 mV, respectively (for e-fold change; difference not significant). Bottom: there was no significant change in the voltage dependence of activation of the sustained component. Best-fit shared parameters were -9.3 mV for V_1/2and 15.1 mV for Hill slope.