Table 2.
NNS use during the first 21 full days of treatment; data from 1050 days of observation from 50 patients.*
| NNS 1 dose per hour |
NNS Ad libitum |
Wald Chi2 test | ICC‡ | |
| Mean (CI 95%) | Mean (CI 95%) | p-value | ρ | |
| Doses | ||||
| Daily number of intakes | 13.6 (4.7; 22.6) | 11.1 (7.3; 14.8) | p = 0.332 | ρ = 0.606 |
| Daily number of correct doses (2 puffs) | 12.0 (3.9; 20.2) | 9.3 (5.9; 12.7) | p = 0.263 | ρ = 0.593 |
| Daily number of single puff | 0.5 (-0.4; 1.5) | 0.8 (0.4; 1.2) | p = 0.470 | ρ = 0.414 |
| Daily number of doses over 2 puffs | 1.1 (-0.1; 2.2) | 1.0 (0.5;1.4) | p = 0.780 | ρ = 0.331 |
| Period of use | ||||
| Daily intake 1st week | 13.7 (3.6; 23.8) | 12.9 (8.7; 17.1) | p = 0.788 | ρ = 0.798 |
| Daily intake 2nd week | 14.5 (4.4;24.6) | 10.5 (6.3; 14.7) | p = 0.184 | ρ = 0.696 |
| Daily intake 3rd week | 12.8 (5.6; 22.2) | 9.8 (5.8;13.7) | p = 0.287 | ρ = 0.656 |
| Week days | ||||
| Daily intake weekends | 13.2 (4.3; 22.2) | 9.7 (6.0;13.4) | p = 0.189 | ρ = 0.525 |
| Daily intake weekdays | 13.8 (4.5; 23.1) | 11.6 (7.7; 15.4) | p = 0.419 | ρ = 0.652 |
| Use of NNS | ||||
| Days NNS was used† | 22.9 (19.0; 27.3) | 23.0 (18.8;27.3) | p = 0.966 | - |
| Total nicotine (mg)† | 418 (294; 543) | 296 (188; 405) | p = 0.131 | - |
* Results are drawn from random-effect GLS regression taking lack of independence from measurements from the same patients into consideration.
† Individual level data was used for this analysis. T-test was used to calculate p-value.
‡ The Intraclass Correlation Coefficient (ρ) corresponds to the percentage of variance due to individual characteristics (cluster level).