TABLE 1.

Urinary excretion of MDMA and its metabolites (males)

Volunteer Code	CYP2D6 Genotype	MDMA	Dose	Excreted 0 to 4 h (Males)
				MDMA	MDA	HMMA	HMA	N-Ac-5-Cys-HHMA	N-Ac-5-Cys-HHA	Total
		mg	mg/kg	μmol
11	*1/*4	90	1.4	33.7	0.94	9.9	1.13	0.0016	0.0002	45.64
12	*1/*10	80	1.5	12.8	0.65	12.3	1.11	0.0041	ND	26.88
13	*1/*2	100	1.4	9.4	0.75	26.3	1.50	0.0062	ND	37.88
14	*1/*9	100	1.1	4.5	0.37	6.2	0.77	0.0163	0.0040	11.84
15	*2/*41	90	1.5	9.7	0.76	7.1	1.44	ND	0.0012	19.08
16	*1/*2	100	1.4	3.3	0.58	19.9	1.30	0.0102	0.0025	25.16
18	*9/*10	100	1.2	2.7	0.30	2.9	0.52	0.0022	0.0017	6.43
20	*2/*4	100	1.4	25.1	0.67	11.5	0.51	0.0010	0.0004	37.85
21	*1/*2	100	1.5	10.9	0.50	16.5	0.95	0.0160	0.0036	28.85
22	*1/*2	100	1.5	45.2	2.25	9.8	1.70	0.0012	0.0028	58.91
23	*1/*2	80	1.4	68.3	3.04	16.8	3.52	0.0031	0.0055	91.67
Mean				20.5	0.98	12.7	1.31	0.0062	0.0024	35.47
S.D.				6.3	0.25	2.0	0.24	0.0018	0.0005	7.21
Recovery as % of dose				4.0	0.19	2.5	0.25	0.0012	0.0005	6.94

ND, not detected.