TABLE 2.
Urinary excretion of MDMA and its metabolites (females)
|
Volunteer Code
|
CYP2D6 Genotype
|
MDMA
|
Dose
|
Excreted 0-4 h (Females)
|
||||||
|---|---|---|---|---|---|---|---|---|---|---|
| MDMA | MDA | HMMA | HMA | N-Ac-5-Cys-HHMA | N-Ac-5-Cys-HHA | Total | ||||
| mg | mg/kg | μmol | ||||||||
| 17 | *2/*10 | 80 | 1.3 | 46.4 | 1.64 | 16.34 | 0.9 | 0.0042 | 0.0013 | 65.36 |
| 19 | *1/*2 | 75 | 1.5 | 19.7 | 0.96 | 32.93 | 1.8 | 0.0088 | 0.0018 | 55.41 |
| 26 | *1/*10 | 75 | 1.5 | 15.5 | 1.35 | 38.92 | 2.2 | 0.0049 | 0.0015 | 58.03 |
| 27 | *1/*35 | 75 | 1.4 | 7.9 | 0.49 | 16.86 | 1.1 | 0.0091 | 0.0019 | 26.39 |
| Mean | 22.4 | 1.11 | 26.26 | 1.5 | 0.0070 | 0.0020 | 51.30 | |||
| S.D. | 8.4 | 0.25 | 5.71 | 0.3 | 0.0013 | 0.0001 | 8.57 | |||
| Recovery as % of dose | 4.3 | 0.21 | 5.07 | 0.3 | 0.0013 | 0.0003 | 9.88 | |||