Table 1.
Population distribution of the R229Q OGG1 polymorphism. The NIH Single Nucleotide Polymorphism database (dbSNP) (http://www.ncbi.nlm.nih.gov/projects/SNP/) was searched for validated OGG1 polymorphisms. Genotype frequencies and corresponding allele frequencies for individuals homozygous for wild-type OGG1 (G/G) and heterozygous for R229Q (A/G) are shown for 6 analyzed populations (refSNP ID: rs1805373). Sampled populations are NIHPDR, NIH polymorphism discovery resource; PDR90, 90-individual subset of NIHPDR; CEU, Utah residents with northern and western European ancestry; HCB, Han Chinese in Beijing, China; JPT, Japanese in Tokyo, Japan and YRI, Yoruba in Ibadan, Nigeria.
| Sample Collection | Genotypes | Alleles | ||||
|---|---|---|---|---|---|---|
| Population | Group | Individuals | G/G | A/G | G | A |
| NIHPDR | Global | 420 | 0.936 | 0.064 | 0.968 | 0.032 |
| PDR90 | Global | 78 | 0.936 | 0.064 | 0.968 | 0.032 |
| HapMap-CEU | European | 60 | 1.000 | - | 1.000 | - |
| HapMap-HCB | Asian | 45 | 1.000 | - | 1.000 | - |
| HapMap-JPT | Asian | 44 | 1.000 | - | 1.000 | - |
| HapMap-YRI | African | 60 | 0.800 | 0.200 | 0.900 | 0.100 |
|
| ||||||
| Total Samples | 707 | 0.938 | 0.062 | 0.969 | 0.031 | |