Figure 5. Performance of tumor-only analysis using CNNLOH Quantifier and SOMATICS on simulated data corresponding to virtual mixtures of normal and tumor cells.

Data corresponding to varying fractions of normal and tumor cells was simulated using data from normal cells and microdissected tumor cells from the same lung cancer tumor. The performance of the two algorithms was evaluated as sensitivity (A) and specificity (B) compared to CNNLOH detected by dChip in a paired analysis of SNP array data of the normal and tumor cells.