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. Author manuscript; available in PMC: 2010 May 15.
Published in final edited form as: Cell. 2009 May 15;137(4):672–684. doi: 10.1016/j.cell.2009.03.035

Figure 6. Centromere and Kinetochore Protein Architecture, Mechanics, Tension Sensing and Force Generation.

Figure 6

Schematics of the Ndc80 arm (A) and the hKnl1 arm (B) revealed by comparison of control and taxol-treated metaphase cells. (C) A tension/SAC activation-dependent intra-kinetochore switch produced by a 15 nm translocation of the Ndc80 arm relative to the hKnl1 arm. This translocation is proposed to occur by rotation of Mis12 and hDsn1 subunits coupled to relaxation of a flexible filament-like linkage between the Ndc80 Arm and the inner kinetochore. (D–F) Models of the protein architecture of the KMN network of proteins within a kinetochore MT attachment site for depolymerizing ends (D), polymerizing ends (E), and taxol-stabilized ends (F).