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. 2009 Apr;133(4):405–419. doi: 10.1085/jgp.200810186

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© 2009 Tsai et al.

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Figure 7. — The effect of MgPPi can be modulated by altering the ligand–NBD1 interaction. (A) WT channels were exposed to 2 mM MgPPi solution immediately after washout of 2 mM ATP or 50 µM P-ATP. (B) The lock-open efficiency of MgPPi was reduced by the W401G mutation, and P-ATP can partially restore the effectiveness of MgPPi on W401g-CFTR. (C) Summary of data presented in A and B. *, P < 0.01.