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. 2009 Apr;133(4):405–419. doi: 10.1085/jgp.200810186

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© 2009 Tsai et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jgp.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 8. — Multiple closed states of WT-CFTR. (A) Upon washout of ATP, the first closing step (O→C₂) involves ATP hydrolysis and dissociation of hydrolytic products from the NBD2 site. The second step (C₂→C₁) is regulated by a slow dissociation of ATP from the NBD1 site. The two closed states respond to MgPPi differently. (B) Reapplication of ATP brings the channel in the C₁ state to a hypothetical C₂* state with one ATP bound in NBD1. Double arrows between each state reflect the likely existence of other unidentified closed states.