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. 2009 Apr;133(4):405–419. doi: 10.1085/jgp.200810186

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© 2009 Tsai et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jgp.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 9. — Effects of PPi are facilitated by channel opening. (A) A continuous current trace of Y1219G-CFTR. After the channels were activated by PKA and ATP, phosphorylated channels were first exposed to either 500 µM or 20 mM ATP. Subsequent application of 2 mM MgPPi locked open the channels more efficiently when the channels were first opened by 20 mM ATP. (B) Comparison of the current increase 10 s after the addition of MgPPi (n = 6; P < 0.05). Paired samples statistics: 21.7 ± 7.9 pA (500 µM ATP) and 73.8 ± 30.1 pA (20 mM ATP). (C) Comparison of the current increase 2 min after the addition of MgPPi (n = 6; P < 0.05). Paired samples statistics: 84.5 ± 37.2 pA (500 µM ATP) and 190.1 ± 72.8 pA (20 mM ATP).